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KMID : 0374019850080030171
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Ewha Medical Journal
1985 Volume.8 No. 3 p.171 ~ p.179
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The Effects of Phototherapy Lights on the Cytochrome Enzyme System and Riboflavin Status in the Newborn Rats
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Abstract
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The effectiveness of phototherapy in the treatment of neonatal hyperbilirubinemia is so established that it is widely used without serious side effects. The widespread
- - use of phototherapy has caused some concern since substances other than bilirubin may be photoactivated or photo decomposed. The toxic properties of these photoactivated substances might prove to be more harmful to the neonatal infants than bilirubin.
The purpose of the present study was to investigate the photodynamic metabolic effects on the hepatic microsomal cytochrome P-450, cytochrome b5, riboflavin status, hepatic microsomal DNA and RNA of newborn rats at 1 week and 3weeks of illumination by phototherapy lights.
The results are as follows
1 ) Activities of hepatic microsomal cytochrome P450 and cytochrome b. in newborn rats increased significantly at 3 weeks of illumination by phototherapy lights.
2 ) Induced cytochrome P450 by phototherapy lights increased the ring-hydro-
xylation of AAF., more significantly (P<0.001 ) than the N-hydroxylation(P<001).
3) Erythrocyte glutathione reductase activity coefficient as a measure of ribo-
flavin status increased significantly( P<0.05) at 1 and 3 weeks of illumination by
phototherapy lights,. and this means the riboflavin deficiency due to the photodecomposition of riboflavin by phototherapy lights.
4) The quantative measurement of hepatic microsomal DNA and RNA showed no significant change by phototherapy lights.
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